Comparison of various low density lipoprotein cholesterol calculators. Is it time for the Friedewald equation to go?

Abstract Aim Plasma low density lipoprotein cholesterol (LDL-C) is a unit measure of mass & an estimate circulating LDL-C. LDL-C commonly calculated indirectly by Friedewald equation and not directly with enzymatic method. The underestimates the LDLC compared to direct particularly in patients high Triglycerides (TGL). Recently developed Sampson (2020) also estimates but less dependent on TGL values. present study compares measured above friedewald sampsons equations. Methodology A Multicentric (three health centers) method 8332 samples. data was collected using electronic database computed Microsoft excel. Retrospective analysis performed after ethical committee approval waiver consent. values derived from Subgroup for accuracy done among various subgroups such as than 50 mg/dl, 50–70 70–150 mg/dl more 150 mg/dl. entire cohort subdivided into triglyceride <150 150–450 >450 Results Our results shows that mean 85.7mg/dl, were 80mg/dl 76mg/dl respectively. There statistical significance difference when combined per Games - Howell multiple comparison which Friedewal's equation. overall concordance upwards between Friedewald's versus similar (81% 83% respectively). discordance (4%), unlike 1.5% downwards Sampson's (12%) unlike, 16% showed accurate But had close proximity magnitude noted Conclusions better friedewald's estimation ideal, better, easily incorporated. We have simple android application both recommend sampson's can be utilized third world developing countries planning targets during secondary prevention. Funding Acknowledgement Type funding sources: None.